Migrant in my own country: The long march of migrant workers in India during the COVID-19 pandemic 2020-Failure of postcolonial governments to decolonize Bihar and rebuild Indian civilization after 1947

Migrant in my own country: The long march of migrant workers in India during the COVID-19 pandemic 2020-Failure of postcolonial governments to decolonize Bihar and rebuild Indian civilization after 1947

The world is passing by way of the unprecedented disaster of COVID 19 pandemic. A big part of the world inhabitants has been dwelling underneath necessary mass quarantine, the lockdown, as a technique in the direction of slowing down the enlargement of the pandemic. This lockdown is being eased out throughout world in a part sensible method. India being one of the most populous nations is hardest hit by the pandemic and quickly the quantity of constructive circumstances is probably going to contact a million mark. Nothing has modified for the migrant workers by way of the previous three centuries, together with the first century of postcolonial India. Why are they known as migrant workers?

One of the most important phenomenons noticed during the Indian lockdown, has emerged as the long march of migrant workers from cities to their native locations. Bihar, one of the Indian provinces is the main supplier of migrant labourers for Indian agriculture and the business sectors. As depicted on social media and tv, the plight of migrants was disturbing and uncovered fashionable Indian democracy’s vulnerabilities. Many of them had to stroll on foot for 1000’s of kilometers, with their hungry households, from the industrial cities to their native locations.

Are they not residents of India? How come being Bihari-a native of Bihar province, one of the main sources of migrant workers in India, develop into a stigma? So how did the historic image of the most important accomplishments of Indian historical past, literature, science, and tradition come to be recognized with poor migrant workers’ picture? Bihar’s underdevelopment is commonly blamed on corrupt native politicians and caste politics. However, the historical past of migrant workers from Bihar and japanese Uttar Pradesh states of India is price a more in-depth consideration for doable options.

The phenomenon has a historic linkage with the fall of as soon as upon a time the nice Indian civilization; centuries of occupation, colonization, slavery, and indentured servitude. India has made regular progress in financial phrases since 1947, India’s independence from the British empire. The financial system’s dimension and rise in gross home product (GDP) are meaningless if atypical residents proceed to be disfranchised, not protected, and liberated from the colonial processes. For India’s sovereign financial growth, there isn’t a choice however to make investments in long-term and rebuild the civilization and construct a system of the indigenous Indian information financial system based mostly on the core ideas and values of the Indian civilization.

Sovereign Credit Default Swap and Stock Markets in Central and Eastern European Countries: Are Feedback Effects at Work?

 

The objective of the paper is to examine the relationship between sovereign Credit Default Swap (CDS) and inventory markets in 9 rising economies from Central and Eastern Europe (CEE), utilizing every day knowledge over the interval January 2008-April 2018. The evaluation deploys a Vector Autoregressive mannequin, specializing in the path of Granger causality between the credit score and inventory markets. We discover proof of the presence of bidirectional suggestions between sovereign CDS and inventory markets in CEE nations.

The outcomes spotlight a switch entropy of danger from the non-public to public sector over the entire interval and respectively, from the public to non-public switch entropy of danger during the European sovereign debt disaster solely in Romania and Slovenia. Another discovering that deserves explicit consideration is that the linkage between the CDS spreads and inventory markets is time-varying and topic to regime shifts, relying on world monetary situations, similar to the sovereign debt disaster. By offering insights on the inter-temporal causality of the comovements of the CDS-stock markets, the paper has important sensible implications for danger administration practices and regulatory insurance policies, underneath totally different market situations of European rising economies.

Migrant in my own country: The long march of migrant workers in India during the COVID-19 pandemic 2020-Failure of postcolonial governments to decolonize Bihar and rebuild Indian civilization after 1947

Sovereignty, privateness, and ethics in blockchain-based id administration programs

 

Self-sovereign id (SSI) options carried out on the foundation of blockchain expertise are seen as options to present digital identification programs, and even as a basis of requirements for the new world infrastructures for id administration programs. It is argued that ‘self-sovereignty’ in this context will be understood as the idea of particular person management over id related non-public knowledge, capability to select the place such knowledge is saved, and the capacity to present it to those that want to validate it.

It can also be argued that whereas it is perhaps interesting to operationalise the idea of ‘self-sovereignty’ in a slim technical sense, depreciation of ethical semantics obscures key challenges and long-term repercussions. Closer consideration to the normative substance of the ‘sovereignty’ idea helps to spotlight a spread of moral points pertaining to the altering nature of human id in the context of ubiquitous non-public knowledge assortment.

Product not found

The investigation of the systemic significance of monetary establishments (SIFIs) has develop into a sizzling matter in the discipline of monetary danger administration. By making full use of 5-min high-frequency knowledge, and with the assist of the technique of entropy weight approach for order desire by similarities to preferrred resolution (TOPSIS), this paper builds bounce volatility spillover community of China’s monetary establishments to measure the SIFIs. ; (iii) an fascinating discovering reveals that some small monetary establishments are additionally SIFIs during the monetary disaster and can’t be ignored.

ANTI HER2 THERAPIES AGAINST BREAST CANCER

Overexpression of the HER2 protein occurs in approximately 25% of breast cancer cases, resulting in a therapeutic target of great interest against which various anti-HER2 therapies against breast cancer are being developed.

In this post we summarize the main types of anti HER2 therapies that are being incorporated into clinical practice in the approach to breast cancer.

The HER2 protein, also known as ERBB-2, is a 185 kDa tyrosine kinase receptor composed of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular domain with tyrosine kinase activity.

By binding to EGF (Epidermal Growth Factor) ligands, such as TGF-α , AR, EPR or NRG1 , among others, the formation of heterodimers is activated that activate various transduction cascades, resulting in increased proliferation, differentiation, cell mobility and survival.

Overexpression of this receptor and its constant activation leads to uncontrolled cell division and carcinogenesis.

After focusing on the HER2 receptor as a therapeutic target, various treatments aimed at blocking and deactivating it have been developed as a mechanism to treat HER2 + breast cancer.

There are currently three types of anti-HER2 therapies for breast cancer : monoclonal antibodies, TKIs (tyrosine kinase inhibitors) and ADCs (Antibody-drug conjugates).

MONOCLONAL ANTIBODIES (MAB)

Anti HER2 monoclonal antibodies are large molecules with monovalent affinity, produced using recombinant DNA technology.

Its mechanism of action is based on blocking the extracellular ligand binding domain of the HER2 receptor, thus reducing the neoplastic actions of HER2 heterodimers. At the same time, the HER2-antibody complex is internalized and destroyed by the target cell, reducing the number of available HER2 receptors.

Examples of monoclonal antibodies currently used as treatment in breast cancer include humanized antibodies trastuzumab and pertuzumab.

You can expand the information in this entry about Monoclonal Antibodies against breast cancer .

TYROSINE KINASE INHIBITORS (TKI)

Tyrosine kinase inhibitors are smaller molecules than monoclonal anti-HER2 antibodies, and their mechanism of action is based on the inhibition of phosphorylation of the intracellular tyrosine kinase domain of the HER2 receptor.

Most of these compounds target more than one HER receptor, allowing them to simultaneously block two or more components of the heterodimer.

The binding of these compounds to the HER2 receptor can be reversible as in the case of Lapatinib , or irreversible as in the case of Canertinib .

ANTIBODY-DRUG CONJUGATES (ADC)

ADCs are a special type of therapeutic antibody, consisting of an anti-HER2 monoclonal antibody conjugated to a chemotherapeutic drug. Its mechanism of action is based on the internalization of the antibody-drug complex and its intracellular cytotoxic activity.

The selection of the antigen for the development of this type of therapeutic agents is critical to achieve maximum specificity and consequently less toxicity, with optimal antigens being those that are expressed with high density on the surface of cancer cells, and do not do so in healthy cells.

An example of ADC against breast cancer would be trastuzumab emtansine (T-DM1).

5 METHODS TO QUANTIFY PROTEINS

The precise quantification of the proteins in a sample is essential for studying them in an infinity of research areas.

While the quantification of a specific protein can be carried out by means of tests such as Western Blot or ELISA , by mass spectrometry (MS) or by other methods such as those based on nanoparticles, there are tests that allow quantifying the concentration of total protein present in a shows.

This last case is the one we focus on this week, compiling a brief description of the 5 main methods to quantify total proteins .

1.- BICINCHONINIC ACID (BCA)
  • Concentration range : 20-2000 ug / ml
  • Features :
    • Developed in 1985
    • Colorimetric test where the absorbance will be proportional to the concentration of protein present in the sample
    • Two-step reaction:
      • Formation of protein-copper ion complexes
      • Formation of a Cu-BCA chelate resulting in an intense purple coloration that absorbs at 562nm
    • It is a recommended method in the case of samples containing> 5% detergents and / or denaturing agents such as urea or guanidinium chloride.
  • Limitations :
    • Samples containing substances that interact with copper, such as ammonia, like EDTA, reducing sugars, or lipids, may interfere with this assay.
2.- ULTRAVIOLET (UV) ABSORPTION
  • Concentration range : 0.1-100 ug / ml
  • Features :
    • This method, by measuring the characteristic absorption of tryptophan and tyrosine at 280nm, estimates the amount of protein present in the sample.
  • Limitations :
    • It is incompatible with protein extraction methods that use detergents and / or denaturing agents.
    • It is not a specific method for proteins, since other compounds that could be in the sample also absorb at 280nm (such as alcohols or nucleic acids, among others)
3.- BRADFORD OR COOMASIE BLUE TEST
  • Concentration range : 20-2000 ug / ml
  • Features :
    • Method described in 1976
    • It is characterized by being a quick, simple and compatible method with reducing agents used to stabilize proteins in solution.
    • The negatively charged Coomasie blue stain binds to positively charged proteins.
    • It mainly binds to arginine, tryptophan, tyrosine, histidine and phenylalanine residues.
    • The solution stain is red and absorbs at 465nm, while binding to the basic amino acids of a protein it turns blue and absorbs at 595nm.
    • The absorbance measurement is compared with the values ​​of a standard curve to determine the protein concentration of the sample.
  • Limitations :
    • Not valid for detecting proteins of <3kDa
    • It is incompatible with detergents such as SDS or Triton X-100
4.- LOWRY’S ESSAY
  • Concentration range : 10-1000 ug / ml
  • Features :
    • One of the most widely used methods to quantify proteins was developed in 1951
    • It is a very sensitive and precise test
    • Like the BCA assay, a two-step reaction occurs:
      • Formation of Cu-N complexes (present in the protein)
      • The tyrosine and tryptophan complexes react with the Folin-Ciocalteau rectifier, giving rise to a greenish-blue color that absorbs between 650 and 750nm.
    • The absorbance measurement is compared with the values ​​of a standard curve to determine the protein concentration of the sample.
  • Limitations :
    • It is incompatible with certain chemical reagents in common use such as Tris, EDTA, DDT, 2-mercaptoethanol, carbohydrates, etc.
5.- CBQCA (3- (4-CARBOXYBENZOYL) QUINOLINE-2-CARBOXYDEHYDE) ASSAY
  • Concentration range : 100 ng – 1500 ug / ml
  • Features :
    • It is a highly sensitive fluorogenic agent that is used for the detection of primary amines in proteins.
    • The intensity of the fluorescence emitted will be directly proportional to the concentration of protein present in the sample.
    • Does not interact with lipid compounds
  • Limitations :
    • The result depends on the number of certain amino acids present in the protein.

The Embodied Brain of SOVEREIGN2: From Space-Variant Conscious Percepts During Visual Search and Navigation to Learning Invariant Object Categories and Cognitive-Emotional Plans for Acquiring Valued Goals.

The Embodied Brain of SOVEREIGN2: From Space-Variant Conscious Percepts During Visual Search and Navigation to Learning Invariant Object Categories and Cognitive-Emotional Plans for Acquiring Valued Goals.

This article develops a mannequin of how reactive and deliberate behaviors work together in actual time. Controllers for each animals and animats want reactive mechanisms for exploration, and realized plans to effectively attain purpose objects as soon as an surroundings turns into acquainted.

The SOVEREIGN mannequin embodied these capabilities, and was examined in a 3D digital actuality surroundings. Neural fashions have characterised vital adaptive and clever processes that weren’t included in SOVEREIGN. A serious analysis program is summarized herein by which to constantly incorporate them into an enhanced mannequin known as SOVEREIGN2.

Key new perceptual, cognitive, cognitive-emotional, and navigational processes require suggestions networks which regulate resonant mind states that assist aware experiences of seeing, feeling, and realizing. Also included are computationally complementary processes of the mammalian neocortical What and Where processing streams, and homologous mechanisms for spatial navigation and arm motion management.

These embody: Unpredictably shifting targets are tracked utilizing coordinated easy pursuit and saccadic actions. Estimates of goal and current place are computed within the Where stream, and can activate strategy actions. Motion cues can elicit orienting actions to deliver new targets into view.

Cumulative motion estimates are derived from visible and vestibular cues. Arbitrary navigational routes are incrementally realized as a labeled graph of angles turned and distances traveled between turns.

Noisy and incomplete visible sensor knowledge are remodeled into representations of visible type and movement. Invariant recognition classes are realized within the What stream. Sequences of invariant object classes are saved in a cognitive working reminiscence, whereas sequences of motion positions and instructions are saved in a spatial working reminiscence.

Stored sequences set off studying of cognitive and spatial/motor sequence classes or plans, additionally known as listing chunks, which management deliberate selections and actions towards valued purpose objects. Predictively profitable listing chunk mixtures are selectively enhanced or suppressed by way of reinforcement studying and incentive motivational studying.

Expected vs. surprising occasion disconfirmations regulate these enhancement and suppressive processes. Adaptively timed studying permits consideration and motion to match process constraints. Social cognitive joint consideration permits imitation studying of expertise by learners who observe academics from totally different spatial vantage factors.

The Embodied Brain of SOVEREIGN2: From Space-Variant Conscious Percepts During Visual Search and Navigation to Learning Invariant Object Categories and Cognitive-Emotional Plans for Acquiring Valued Goals.
The Embodied Brain of SOVEREIGN2: From Space-Variant Conscious Percepts During Visual Search and Navigation to Learning Invariant Object Categories and Cognitive-Emotional Plans for Acquiring Valued Goals.

Twenty Years of Military Prehospital Care within the Eastern Sovereign Base Area, Cyprus.

The Medical Reception Station (MRS) in Dhekelia supplies a prehospital emergency care (PHEC) service for the Eastern Sovereign Base Area and surrounding Cypriot cities.

This service has been evaluated beforehand however some vital elements of care haven’t but been measured. The major goal of this examine was to undertake essentially the most complete service analysis of the demand for the PHEC service at MRS Dhekelia over a 12-month interval.

The secondary goal of this examine was to evaluate findings in 2018 to these in 1995-1998 and 2013-2016.All calls to the PHEC crew between 01/07/2017 and 30/06/2018 had been reviewed and in contrast with beforehand reported knowledge from 1995 to 1998 and 2013 to 2016. Data had been collected from the prevalence ebook, the logbook utilized by the PHEC crew to file the small print of every name.There had been 164 calls to the PHEC service in the course of the present examine interval. The quantity of activations has decreased for the reason that 2013-2016 interval however stays larger than 1995-1998.

In each month there was a name to a scene the place a couple of casualty was current, with the very best quantity being 9 sufferers at one name. More calls had been obtained in the course of the day (55%). There had been extra calls as a result of of trauma than medical complaints (55% vs 45%). Trauma calls have decreased over 20 years.

The frequency of neurological and psychiatric complaints has elevated over 20 years.The PHEC service at MRS Dhekelia is ceaselessly used. The crew constantly face with scenes with a couple of casualty. Trauma is turning into much less frequent however psychiatric and neurological complaints are more and more frequent. These findings are vital for coaching and service provision.

Bioactive Compounds of Aristotelia chilensis Stuntz and their Pharmacological Effects

Bioactive Compounds of Aristotelia chilensis Stuntz and their Pharmacological Effects

Aristotelia chilensis ([Molina], Stuntz) a member of the household Eleocarpaceae, is a plant native to Chile that’s distributed in tropical and temperate Asia, Australia, the Pacific Space, and South America.

The juice of its berries has essential medicinal properties, as an astringent, tonic, and antidiarrhoeal. Its many qualities make the maqui berry the undisputed sovereign of the household of so-called “superfruits”, in addition to a beneficial instrument to fight mobile irritation of bones and joints. Just lately, it’s found that the leaves of the maqui berry have essential antibacterial and antitumour actions.

This evaluate gives a complete overview of the normal use, phytochemistry, and organic exercise of A. chilensis utilizing info collected from scientific journals, books, and digital searches. Anthocyanins, different flavonoids, alkaloids, cinnamic acid derivatives, benzoic acid derivatives, different bioactive molecules, and mineral components are summarized.

 Bioactive Compounds of Aristotelia chilensis Stuntz and their Pharmacological Effects
Bioactive Compounds of Aristotelia chilensis Stuntz and their Pharmacological Results

A broad vary of actions of plant extracts and fractions are introduced, together with antioxidant exercise, inhibition of seen light-induced harm of photoreceptor cells, inhibition of α-glucosidase, inhibition of pancreatic lipase, anti-diabetic results, anti-inflammatory results, analgesic results, anti-diabetes, efficient prevention of atherosclerosis, promotion of hair progress, anti-photo ageing of the pores and skin, and inhibition of lipid peroxidation.

Though some ethnobotanical makes use of have been supported in in vitro experiments, additional research of the person compounds or chemical courses of compounds accountable for the pharmacological results and the mechanisms of motion are crucial. As well as, the toxicity and the uncomfortable side effects from using A. chilensis, in addition to scientific trials, require consideration.

Aristotelia chilensis ([Molina], Stuntz) a member of the household Eleocarpaceae, is a plant native to Chile that’s distributed in tropical and temperate Asia, Australia, the Pacific Space, and South America.

The juice of its berries has essential medicinal properties, as an astringent, tonic, and antidiarrhoeal. Its many qualities make the maqui berry the undisputed sovereign of the household of so-called “superfruits”, in addition to a beneficial instrument to fight mobile irritation of bones and joints. Just lately, it’s found that the leaves of the maqui berry have essential antibacterial and antitumour actions. This evaluate gives a complete overview of the normal use, phytochemistry, and organic exercise of A.

chilensis utilizing info collected from scientific journals, books, and digital searches. Anthocyanins, different flavonoids, alkaloids, cinnamic acid derivatives, benzoic acid derivatives, different bioactive molecules, and mineral components are summarized.

A broad vary of actions of plant extracts and fractions are introduced, together with antioxidant exercise, inhibition of seen light-induced harm of photoreceptor cells, inhibition of α-glucosidase, inhibition of pancreatic lipase, anti-diabetic results, anti-inflammatory results, analgesic results, anti-diabetes, efficient prevention of atherosclerosis, promotion of hair progress, anti-photo ageing of the pores and skin, and inhibition of lipid peroxidation.

Though some ethnobotanical makes use of have been supported in in vitro experiments, additional research of the person compounds or chemical courses of compounds accountable for the pharmacological results and the mechanisms of motion are crucial. As well as, the toxicity and the uncomfortable side effects from using A. chilensis, in addition to scientific trials, require consideration.

Delphinidin anthocyanins have beforehand been related to the inhibition of glucose absorption. Blood glucose reducing results have been ascribed to maqui berry (Aristotelia chilensis) extracts in people after boiled rice consumption.

On this research, we aimed to discover whether or not a standardized delphinidin-rich extract from maqui berry (Delphinol) impacts glucose metabolism in prediabetic people primarily based on glycemia and insulinemia curves obtained from an oral glucose tolerance check (OGTT) after a problem with pure glucose. Volunteers underwent 4 consecutive OGTTs with a minimum of one week washout interval, by which completely different doses of Delphinol had been administered one hour earlier than glucose consumption.

Delphinol considerably and dose-dependently lowered basal glycemia and insulinemia. Decrease doses delayed postprandial glycemic and insulinemic peaks, whereas increased doses reversed this tendency. Glycemia peaks had been dose-dependently lowered, whereas insulinemia peaks had been increased for the bottom dose and decrease for different doses. The full glucose obtainable in blood was unaffected by remedies, whereas the overall insulin availability was elevated by low doses and decreased by the very best dose.

Taken collectively, these open exploratory outcomes recommend that Delphinol might be performing by way of three doable mechanisms: by inhibition of intestinal glucose transporters, by an incretin-mediated impact, or by bettering insulin sensitivity.